1. Mollaoglu G, Tepper A, Falcomatà C, Potak HT, Pia L, Amabile A, Mateus-Tique J, Rabinovich N, Park MD, LaMarche NM, Brody R, Browning L, Lin JR, Zamarin D, Sorger PK, Santagata S, Merad M, Baccarini A, Brown BD. Ovarian cancer-derived IL-4 promotes immunotherapy resistance.  Cell. In Press.

  2. Park MD, Le Berichel J, Hamon P, Wilk CM, Belabed M, Yatim N, Saffon A, Boumelha J, Falcomatà C, Tepper A, Hegde S, Mattiuz R, Soong BY, LaMarche NM, Rentzeperis F, Troncoso L, Halasz L, Hennequin C, Chin T, Chen EP, Reid AM, Su M, Cahn AR, Koekkoek LL, Venturini N, Wood-Isenberg S, D'souza D, Chen R, Dawson T, Nie K, Chen Z, Kim-Schulze S, Casanova-Acebes M, Swirski FK, Downward J, Vabret N, Brown BD, Marron TU, Merad M. Hematopoietic aging promotes cancer by fueling IL-1⍺-driven emergency myelopoiesis. Science. 2024 Sep 5:eadn0327.

  3. You Y, Dunst J, Ye K, Sandoz PA, Reinhardt A, Sandrock I, Comet NR, Sarkar RD, Yang E, Duprez E, Agudo J, Brown BD, Utz PJ, Kastenmüller W, Gerlach C, Prinz I, Önfelt B, Kreslavsky T. Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes. Nature Immunology. 2024 Aug;25(8):1367-1382.

  4. Burton OT, Bricard O, Tareen S, Gergelits V, Andrews S, Biggins L, Roca CP, Whyte C, Junius S, Brajic A, Pasciuto E, Ali M, Lemaitre P, Schlenner SM, Ishigame H, Brown BD, Dooley J, Liston A. The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program. Immunity. 2024 Jul 9;57(7):1586-1602.e10.

  5. Wang S, Zhang Y, Zhong Y, Xue Y, Liu Z, Wang C, Kang DD, Li H, Hou X, Tian M, Cao D, Wang L, Guo K, Deng B, McComb DW, Merad M, Brown BD, Dong Y. Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle-mRNA formulation. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2322935121.

  6. LaMarche NM, Hegde S, Park MD, Troncoso L, Le Berichel J, Maier B, Hamon P, Belabed M, Mattiuz R,Hennequin C, Chin T, Reid AM, Reyes-Torres I, Nemeth E, Zhang R, Olson OC, Doroshow DB, Rohs NC, Gomez JE, Veluswamy R, Hall N, Venturini N, Ginhoux F, Liu Z, Miyake K, Karasuyama H, Passegué E, Kim-Schulze S, Brown BD, Hirsch FR, Kim BS, Marron TU, and Merad M.  An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis. Nature. 2024 Jan;625(7993):166-174.

  7. Brown BD, Fauci AS, Belkaid Y, Merad M. RNA vaccines: A transformational advance. Immunity. 2023 Dec 12;56(12):2665-2669.

  8. Aleynick M, Svensson-Arvelund J, Pantsulaia G, Kim K, Rose SA, Upadhyay R, Yellin M, Marsh H, Oreper D, Jhunjhunwala S, Moussion CC, Merad M, Brown BD, Brody JD. Pattern recognition receptor agonists in pathogen vaccines mediate antitumor T-cell cross-priming. Journal of Immunotherapy of Cancer. 2023 Jul;11(7):e007198.

  9. Trinh VQ, Lee TF, Lemoinne S, Ray KC, Ybanez MD, Tsuchida T, Carter JK, Agudo J, Brown BD, Akat KM, Friedman SL, Lee YA. Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation. Science Signaling. 2023 May 30;16(787):eadf6696.

  10. Park MD, Reyes-Torres I, LeBerichel J, Hamon P, LaMarche NM, Hegde S, Belabed M, Troncoso L, Grout JA, Magen A, Humblin E, Nair A, Molgora M, Hou J, Newman JH, Farkas AM, Leader AM, Dawson T, D'Souza D, Hamel S, Sanchez-Paulete AR, Maier B, Bhardwaj N, Martin JC, Kamphorst AO, Kenigsberg E, Casanova-Acebes M, Horowitz A, Brown BD, De Andrade LF, Colonna M, Marron TU, Merad M. TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer. Nature Immunology. 2023 May;24(5):792-801.

  11. Baysoy A, Seddu K, Salloum T, Dawson CA, Lee JJ, Yang L, Gal-Oz S, Ner-Gaon H, Tellier J, Millan A, Sasse A, Brown B, Lanier LL, Shay T, Nutt S, Dwyer D, Benoist C; Immunological Genome Project Consortium. The interweaved signatures of common-gamma-chain cytokines across immunologic lineages. Journal of Experimental Medicine. 2023 Jul 3;220(7):e20222052.

  12. Mateus-Tique J, Brown B. Tumour antigen spreading mediated by vaccine-boosted CAR T cells. Nature Reviews Immunology. 2023 Jan;23(1):7. doi: 10.1038/s41577-022-00811-3. PMID: 36434108.

  13. Svensson-Arvelund J, Cuadrado-Castano S, Pantsulaia G, Kim K, Aleynick M, Hammerich L, Upadhyay R, Yellin M, Marsh H, Oreper D, Jhunjhunwala S, Moussion C, Merad M, Brown BD, Garcia-Sastre A, Brody J. Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity. Nature Communications. 2022 Nov 22;13(1):7149.

  14. Sanchez-Paulete AR*, Mateus-Tique J*, Mollaoglu G, Nielsen SR, Marks A, Lakshmi A, Khan JA, Wilk CM, Pia L, Baccarini A, Merad M, Brown BD. Targeting macrophages with CAR T cells delays solid tumor progression and enhances anti-tumor immunity. Cancer Immunol Res. 2022 Sep 12:CIR-21-1075.

  15. Lin MJ, Svensson-Arvelund J, Lubitz GS, Marabelle A, Melero I, Brown BD, Brody JD. Cancer vaccines: the next immunotherapy frontier. Nature Cancer. 2022 Aug;3(8):911-926.

  16. Chen ST, Park MD, Del Valle DM, Buckup M, Tabachnikova A, Simons NW, Mouskas K, Lee B, Geanon D, D'Souza D, Dawson T, Marvin R, Nie K, Thompson RC, Zhao Z, LeBerichel J, Chang C, Jamal H, Chaddha U, Mathews K, Acquah S, Brown SA, Reiss M, Harkin T, Feldmann M, Powell CA, Hook JL, Kim-Schulze S, Rahman AH, Brown BD; Mount Sinai COVID-19 Biobank Team, Beckmann ND, Gnjatic S, Kenigsberg E, Charney AW, Merad M. Shift of lung macrophage composition is associated with COVID-19 disease severity and recovery. Science Translational Medicine. 2022 Sep 14;14(662):eabn5168.

  17. Kim EH, Manganaro L, Schotsaert M, Brown BD, Mulder LCF, Simon V. Development of an HIV reporter virus that identifies latently infected CD4+ T cells. Cell Reports Methods. 2022 Jun 13;2(6):100238.

  18. Moubarak RS, Koetz-Ploch L, Mullokandov G, Gaziel A, de Pablos-Aragoneses A, Argibay D, Kleffman K, Sokolova E, Berwick M, Thomas NE, Osman I, Brown BD, Hernando E. In Vivo miRNA Decoy Screen Reveals miR-124a as a Suppressor of Melanoma Metastasis. Frontiers in Oncology. 2022 Apr 4;12:852952.

  19. Marron TU, Galsky MD, Taouli B, Fiel MI, Ward S, Kim E, Yankelevitz D, Doroshow D, Guttman-Yassky E, Ungar B, Mehandru S, Golas BJ, Labow D, Sfakianos J, Nair SS, Chakravarty D, Buckstein M, Song X, Kenigsberg E, Gnjatic S, Brown BD, Sparano J, Tewari A, Schwartz M, Bhardwaj N, Merad M. Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery. Nature Medicine. 2022 Apr;28(4):626-629.

  20. Dhainaut M*, Rose SA*, Akturk G, Wroblewska A, Park ES, Nielsen SR, Buckup M, Roudko V, Pia L, Le Berichel J, Wilk CM, Bektesevic A, Lee BH, Sweeney R, Baccarini A, Bhardwaj N, Rahman AH, Gnjatic S, Pe’er D, Merad M, Brown BD. Spatial CRISPR genomics identifies regulators of the tumor microenvironment. Cell. 2022 Mar 31;185(7):1223-1239.e20.

  21. Rose SA, Wroblewska A, Dhainaut M, Yoshida H, Shaffer JM, Bektesevic A, Ben-Zvi B, Rhoads A, Kim E, Yu B, Arakawa-Hoyt J, Lavin Y, Merad M, Buenrostro J, Brown BD. A microRNA expression and regulatory element activity atlas of the mouse immune system. Nature Immunology.  2021 Jul;22(7):914-927.

  22. Casanova-Acebes M, Dalla E, Leader A, LeBerichel J, Nikolic J, Morales BM , Brown M, Chang C, Troncoso L, Chen ST, Sastre-Perona A, Park MD, Tabachnikova A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agulló-Pascual E, Schober M, Brown BD, Reizis B, Kenigsberg E, Moussion C, Benaroch P, Aguirre-Ghiso JA, Merad M. Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature. 2021 Jul;595(7868):578-584.

  23. Bigenwald C, Le Berichel J, Wilk CM, Chakraborty R, Chen ST, Tabachnikova A, Mancusi R, Abhyankar H, Casanova-Acebes M, Laface I, Akturk G, Jobson J, Karoulia Z, Martin JC, Grout J, Rafiei A, Lin H, Manz MG, Baccarini A, Poulikakos PI, Brown BD, Gnjatic S, Lujambio A, McClain KL, Picarsic J, Allen CE, Merad M. BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology. Nature Medicine. 2021 May;27(5):851-861. doi: 10.1038/s41591-021-01304-x. 

  24. Grieshaber-Bouyer R, Radtke FA, Cunin P, Stifano G, Levescot A, Vijaykumar B, Nelson-Maney N, Blaustein RB, Monach PA, Nigrovic PA; ImmGen Consortium.  The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments. Nature Communications. 2021 May 17;12(1):2856. doi: 10.1038/s41467-021-22973-9.

  25. Adamopoulos C, Ahmed TA, Tucker MR, Ung PMU, Xiao M, Karoulia Z, Amabile A, Wu X, Aaronson SA, Ang C, Rebecca VW, Brown BD, Schlessinger A, Herlyn M, Wang Q, Shaw DE, Poulikakos PI. Exploiting allosteric properties of RAF and MEK inhibitors to target therapy-resistant tumors driven by oncogenic BRAF signaling. Cancer Discovery. 2021 Feb 10:candisc.1351.2020. 

  26. Upadhyay R, Boiarsky JA, Pantsulaia G, Svensson-Arvelund J, Lin MJ, Wroblewska A, Bhalla S, Scholler N, Bot A, Rossi JM, Sadek N, Parekh S, Lagana A, Baccarini A, Merad M, Brown BD, Brody JD. A Critical Role for Fas-Mediated Off-Target Tumor Killing in T-cell Immunotherapy. Cancer Discovery. 2020 Dec 17. doi: 10.1158/2159-8290.CD-20-0756. 

  27. Brown BD, Leader AM, Vilcek J, Merad M. "America First" Will Destroy U.S. Science. Cell. 2020 Nov 12;183(4):841-844. 

  28. Vabret N, Britton GJ, Gruber C, Hegde S, Kim J, Kuksin M, Levantovsky R, Malle L, Moreira A, Park MD, Pia L, Risson E, Saffern M, Salomé B, Esai Selvan M, Spindler MP, Tan J, van der Heide V, Gregory JK, Alexandropoulos K, Bhardwaj N, Brown BD, Greenbaum B, Gümüş ZH, Homann D, Horowitz A, Kamphorst AO, Curotto de Lafaille MA, Mehandru S, Merad M, Samstein RM; Sinai Immunology Review Project. Immunology of COVID-19: Current State of the Science. Immunity. 2020 Jun 16;52(6):910-941.

  29. Vabret N, Samstein R, Fernandez N, Merad M; Sinai Immunology Review Project; Trainees; Faculty. Advancing scientific knowledge in times of pandemics. Nature Reviews Immunology. 2020 Jun;20(6):338.

  30. Maier B, Leader AM, Chen ST, Tung N, Chang C, LeBerichel J, Chudnovskiy A, Maskey S, Walker L, Finnigan JP, Kirkling ME, Reizis B, Ghosh S, D'Amore NR, Bhardwaj N, Rothlin CV, Wolf A, Flores R, Marron T, Rahman AH, Kenigsberg E, Brown BD, Merad M. A conserved dendritic-cell regulatory program limits antitumour immunity. Nature. 2020 Apr;580(7802):257-262.

  31. Mullokandov G, Vijayakumar G, Leon P, Henry C, Wilson PC, Krammer F, Palese P, Brown BD. High-complexity extracellular barcoding using a viral hemagglutinin. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2767-2769.

  32. Fiege JK, Stone IA, Dumm RE, Waring BM, Fife BT, Agudo J, Brown BD, Heaton NS, Langlois RA. Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance. PLoS Pathogens. 2019 Sep 26;15(9):e1008077.

  33. Marshall N, Hutchinson K, Marron TU, Aleynick M, Hammerich L, Upadhyay R, Svensson-Arvelund J, Brown BD, Merad M, Brody JD. Anti-tumor T-cell homeostatic activation is uncoupled from homeostatic inhibition by checkpoint blockade. Cancer Discovery. 2019 Aug 2. pii: CD-19-0391.

  34. Kana V, Desland FA, Casanova-Acebes M, Ayata P, Badimon A, Nabel E, Yamamuro K, Sneeboer M, Tan IL, Flanigan ME, Rose SA, Chang C, Leader A, Le Bourhis H, Sweet ES, Tung N, Wroblewska A, Lavin Y, See P, Baccarini A, Ginhoux F, Chitu V, Stanley ER, Russo SJ, Yue Z, Brown BD, Joyner AL, De Witte LD, Morishita H, Schaefer A, Merad M. CSF-1 controls cerebellar microglia and is required for motor function and social interaction. Journal of Experimental Medicine. 2019 Jul 26. pii: jem.20182037.

  35. Ruiz de Galarreta M, Bresnahan E, Molina-Sanchez P, Lindblad KE, Maier B, Sia D, Puigvehi M, Miguela V, Casanova-Acebes M, Dhainaut M, Villacorta-Martin C, Singhi AD, Moghe A, von Felden J, Tal Grinspan L, Wang S, Kamphorst AO, Monga SP, Brown BD, Villanueva A, Llovet JM, Merad M, Lujambio A.  β-catenin activation promotes immune escape and resistance to anti-PD-1 therapy in hepatocellular carcinoma. Cancer Discovery. 2019 Jun 11. pii: CD-19-0074.

  36. Hammerich L, Marron T, Upadhyay T, Svensson-Arvelund J, Dhainaut M, Hussein S, Zhan Y, Ostrowski D, Yellin M, Marsh H, Salazar A, Rahman AH, Brown BD, Merad M, Brody J. Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination.  Nature Medicine. 2019 May;25(5):814-824.

  37. Yoshida H, Lareau CA, Ramirez RN, Rose SA, Maier B, Wroblewska A, Desland F, Chudnovskiy A, Mortha A, Dominguez C, Tellier J, Kim E, Dwyer D, Shinton S, Nabekura T, Qi YL, Yu B, Robinette M, Kim K, Wagers A, Rhoads A, Nutt S, Brown BD, Mostafavi S, Buenrostro J, Benoist C; Immunological Genome Project Consortium. The cis-regulatory atlass of the mouse immune system.  Cell. 2019 Feb 7;176(4):897-912.e20.

  38. Wroblewska A*, Dhainaut M*, Ben-Zvi B, Rose SA, Park ES, Amir ED, Bektesevic A, Baccarini A, Merad M, Rahman AH, Brown BD. Protein barcodes enable high-dimensional single-cell CRISPR screens. Cell. 2018 Oct 16. pii: S0092-8674(18)31234-0.

  39. Agudo J, Park ES, Rose SA, Alibo E, Sweeney R, Dhainaut M, Kobayashi KS, Sachidanandam R, Baccarini A, Merad M, Brown BD. Quiescent tissue stem cells evade immune surveillance. Immunity. 2018 Feb 20; 48(2): 271-285.e5

  40. Jeong D, Yoo J, Lee P, Kepreotis S, Lee A, Whalquist C, Brown B, Kho C, Mercola M, Hajjar R. miR-25 Tough Decoy enhances cardiac function in heart failure. Molecular Therapy. 2017 Nov 26. pii:S1525-0016(17)30573- 7.

  41. Jobson J, Brown BD. Micromanaging tolerance in hemophilia A gene therapy. Molecular Therapy. 2017 Jun 15. pii: S1525-0016(17)30261- 7.

  42. Chia G, Agudo J, Treff N, Sauer MV, Billing D, Brown BD, Baer R, Egli D. Genomic instability during reprogramming by nuclear transfer is DNA replication dependent. Nature Cell Biology. 2017 Apr;19(4):282-291

  43. Chung CY, Sun Z, Mullokandov G, Bosch A, Qadeer ZA, Cihan E, Rapp Z, Parson, R, Aguirre-Ghiso JA, Farias EF, Brown BD, Gaspar-Maia A, Bernstein E. Cbx8 Acts Non-canonically with Wdr5 to Promote Mammary Tumorigenesis. Cell Reports. 2016 Jul 12;16(2):472-86.

  44. Dwyer DF, Barrett NA, Austen KF; Immunological Genome Project Consortium. Expression profiling of constitutive mast cells reveals a unique identity within the immune system. Nature Immunology. 2016 Jul;17(7):878-87.

  45. Salmon H, Idoyaga J, Rahman A, Leboeuf M, Remark R, Jordan S, Casanova-Acebes M, Khudoynazarova M, Agudo J, Tung N, Chakarov S, Rivera C, Hogstad B, Bosenberg M, Hashimoto D, Gnjatic S, Bhardwaj N, Palucka AK, Brown BD, Brody J, Ginhoux F, Merad M. Expansion and Activation of CD103+ Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition. Immunity. 2016 Apr 19;44(4):924-938.

  46. Agudo J, Brown BD. Silence of the ROS. Immunity. 2016 Mar 15;44(3):520-2.

  47. Kidd BA*, Wroblewska A*, Boland MR, Agudo J, Merad M, Tatonetti NP, Brown BD^, Dudley JT. Mapping the effects of drugs on the immune system. Nature Biotechnology. 2016 Jan;34(1):47-54. ^Co-corresponding author.

  48. Brown BD, Merad M. Archives and citation miss equal authors. Nature. 2015 Dec. 16;528(7582):333.

  49. Agudo JA, Ruzo A, Park E, Sweeney R, Kana V, Wu M, Zhao Y, Egli D, Merad M, Brown BD. GFP- specific T cells enable targeted cell depletion and visualization of T-cell interactions. Nature Biotechnology. 2015 Dec;33(12):1287-1292. 

  50. Andikyan V, Mullokandov G, Agudo J, Sachidanandam R, Fishman D, Bacccarini A, Brown BD. MicroRNA activity profile in the ovarian cancer cell line OVCAR3 identifies a proapoptotic effect of miR-23a. Advances in Genomics and Genetics. 2015:5 355-364.

  51. Mulero-Navarro S, Sevilla A, Roman AC, Lee DF, D’Souza S, Pardo S, Riess I, Su J, Cohen N, Schaniel C, Rodriguez NA, Baccarini A, Brown BD, Cavé H, Caye A, Strullu M, Park CY, Yalcin A, Dhandapany PS, Yongchao G, Edelmann L, Bahieg S, Raynal P, Flex E, Tartaglia M, Moore KA, Lemischka IR, Gelb BD. Myeloid dysregulation in a human induced pluripotent stem cell model of PTPN11-associated juvenile myelomonocytic leukemia. Cell Reports. 2015 Oct 20;13(3):504-15.

  52. Upadhyay R, Hammerich L, Peng P, Brown B, Merad M, Brody JD. Lymphoma: Immune Evasion Strategies. Cancers. 2015 Apr 30;7(2):736-62.

  53. Brown BD. A shot in the bone corrects genetic disease. Molecular Therapy. 2015 Apr;23(4):614-5.

  54. Robinette ML, Fuchs A, Cortez VS, Lee JS, Wang Y, Durum SK, Gilfillan S, Colonna M; the Immunological Genome Consortium. Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets. Nature Immunology. 2015 Mar;16(3):306-17.

  55. Hanniford D, Segura M, Jirau-Serrano X, Darvishian F, Berman R, Shapiro R, Pavlick A, Brown BD, Osman I, and Hernando E. Identification of metastasis-suppressive microRNAs in primary melanoma. The Journal of the National Cancer Institute. 2015 Feb 12;107(3).

  56. Israelow B*, Mullokandov G*, Agudo J, Sourisseau M, Bashir A, Brown BD^ and Evans MJ^. Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitors. Nature Communications. 2014 Nov 18;5:5408. ^Co-corresponding.

  57. Mostafavi S, Ortiz-Lopez A, Bogue MA, Hattori K, Pop C, Koller D, Mathis D, Benoist C; Immunological Genome Consortium. Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains. J Immunol. 2014 Nov 1;193(9):4485-96.

  58. Nair-Gupta P, Baccarini A, Tung N, Fabian F, Florey O, Huang Y, Banerjee M, Overholtzer M, Tampé R, Brown BD, Whiteheart SW, and Blander JM. TLRs Control Phagosomal MHC-I Delivery from Endosomal Recycling Compartments to Aid Crosspresentation in Dendritic Cells. Cell. Jul 31;158(3):506-21

  59. Chong RA, Wu K, Spratt DE, Yang Y, Lee C, Nayak J, Xu M, Elkholi R, Tappin I, Li J, Hurwitz J, Brown BD, Chipuk JE, Xhen ZJ, Sanchez R, Shaw GS, Huang L, Pan ZQ. A Pivotal Role for the Ubiquitin Y59-E51 Loop in Lysine-48 Polyubiquitination. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8434-9.

  60. Agudo JA, Ruzo A, Tung N, Salmon H, Leboeuf M, Hashimoto D, Becker C, Garrett-Sinha LA, Baccarini A, Merad M, Brown BD. The microRNA-126/VEGFR2 axis controls the innate response to pathogen-associated nucleic acids. Nature Immunology. 2014 Jan;15(1):54-62.

  61. Parikh A, Lee C, Joseph P, Marchini S, Baccarini A, Kolev V, Romualdi C, Fruscio R, Shah H, Wang FQ, Mullokandov G, Fishman D, D'Incalci M, Rahaman J, Kalir T, Redline R, Brown BD, Narla G, and DiFeo A. microRNA-181a plays a critical role in ovarian cancer progression through the regulation of epithelial-mesenchymal transition. Nature Communications. 2014 Jan 7;5:2977.

  62. Ergun A, Doran G, Costello JC, Paik HH, Collins JJ, Mathis D, Benoist C; ImmGen Consortium. Differential splicing across immune system lineages. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14324-9.

  63. Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C; Immunological Genome Consortium. The transcriptional landscape of ab T cell differentiation. Nature Immunology. 2013 Jun;14(6):619-32.

  64. Jojic V, Shay T, Sylvia K, Zuk O, Sun X, Kang J, Regev A, Koller D; Immunological Genome Project Consortium. Identification of transcriptional regulators in the mouse immune system. Nature Immunology. 2013 Jun;14(6):633-43.

  65. Malhotra N, Narayan K, Cho OH, Sylvia KE, Yin C, Melichar H, Rashighi M, Lefebvre V, Harris JE, Berg LJ, Kang J; Immunological Genome Project Consortium. A network of high-mobility group box transcription factors programs innate interleukin-17 production. Immunity. 2013 Apr 18;38(4):681-93.

  66. Best JA, Blair DA, Knell J, Yang E, Mayya V, Doedens A, Dustin ML, Goldrath AW; Immunological Genome Project Consortium. Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation. Nature Immunology. 2013 Apr;14(4):404-12.

  67. Brown BD. Stealth gene therapy. Blood. 2013 Mar 21;121(12):2168-9.

  68. Cohen NR, Brennan PJ, Shay T, Watts GF, Brigl M, Kang J, Brenner MB; ImmGen Project Consortium. Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells. Nature Immunology. 2013 Jan;14(1):90-9.

  69. Shay T, Jojic V, Zuk O, Rothamel K, Puyraimond-Zemmour D, Feng T, Wakamatsu E, Benoist C, Koller D, Regev A; the ImmGen Consortium. Conservation and divergence in the transcriptional programs of the human and mouse immune systems. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2946-51.

  70. Agudo JA, Ruzo A, Kitur K, Sachidanandam R, Blander JM, Brown BD. A TLR and non-TLR mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade. Molecular Therapy. 2012 Dec;20(12):2257-67.

  71. Helft J, Manicassamy B, Guermonprez P, Hashimoto D, Silvin A, Agudo J, Brown BD, Schmolke M, Miller J, Murphy KM, García-Sastre A, Merad M. Lung CD103+ dendritic cells are resistant to influenza virus infection in vivo and promote cytotoxic T cell immunity through the crossrepresentation of virally infected cells. Journal of Clinical Investigation. 2012 Nov 1;122(11):4037-47.

  72. Gautier EL, Shay T, Miller J, Greter M, Jakubzick C, Ivanov S, Helft J, Chow A, Elpek KG, Gordonov S, Mazloom AR, Ma'ayan A, Chua WJ, Hansen TH, Turley SJ, Merad M, Randolph GJ; The Immunological Genome Project Consortium. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nature Immunology. 2012 Nov;13(11):1118-28.

  73. Bezman NA, Kim CC, Sun JC, Min-Oo G, Hendricks DW, Kamimura Y, Best JA, Goldrath AW, Lanier LL; The Immunological Genome Project Consortium. Molecular definition of the identity and activation of natural killer cells. Nature Immunology.  2012 Oct;13(10):1000-9.

  74. Mullokandov G*, Baccarini A*, Ruzo A*, Jayaprakash AD, Tung N, Israelow B, Evans MJ, Sachidanandam R, Brown BD. High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries. Nature Methods. 2012 Jul 1;9(8):840-6. *equal contribution.  

  75. Miller JC, Brown BD*, Shay T, Gautier EL, Jojic V, Cohain A, Pandey G, Leboeuf M, Elpek KG, Helft J, Hashimoto D, Chow A, Price J, Greter M, Bogunovic M, Bellemare-Pelletier A, Frenette PS, Randolph GJ, Turley SJ, Merad M. Deciphering the transcriptional network of the DC lineage. Nature Immunology. 2012 Sep;13(9):888-99.

  76. Greter M, Helft J, Chow A, Hashimoto D, Mortha A, Agudo-Cantero JA, Bogunovic M, Gautier EL, Miller J, Leboeuf M, Lu G, Aloman C, Brown BD, Pollard JW, Xiong H, Randolph GJ, Chipuk JE, Frenette P, Merad M. GM-CSF controls non-lymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. Immunity. 2012 Jun 29;36(6):1031-46.

  77. Narayan K, Sylvia KE, Malhotra N, Yin CC, Martens G, Vallerskog T, Kornfeld H, Xiong N, Cohen NR, Brenner MB, Berg LJ, Kang J.; The Immunological Genome Project Consortium. Intrathymic programming of effector fates in three molecularly distinct T cell subtypes.Nature Immunology. 2012 Apr 1;13(5):511-8.

  78. Malhotra D, Fletcher AL, Astarita J, Lukacs-Kornek V, Tayalia P, Gonzalez SF, Elpek KG, Chang SK, Knoblich K, Hemler ME, Brenner MB, Carroll MC, Mooney DJ, Turley SJ.; The Immunological Genome Project Consortium. Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nature Immunology.  2012 Apr 1;13(5):499-510.

  79. Chow A, Brown BD, Merad M. Dissecting the Mononuclear Phagocytic System in the Molecular Age. Nature Reviews Immunology. 2011 Oct 25;11(11):788-98.

  80. Jayaprakash A, Jabado O, Brown BD, Sachidanandam R. Identification and remediation of biases in the activity of RNA-ligases in deep sequencing of small RNAs. Nucleic Acids Research. 2011 Nov 1;39(21):e141.

  81. Baccarini A, Chauhan H, Gardner TJ, Jayaprakash AD, Sachidanandam R, Brown BD. Kinetic analysis reveals the fate of a microRNA following target regulation in mammalian cells. Current Biology. 2011 Mar 8;21(5):369-76.

  82. Matsui H, Hegadorn C, Ozelo M, Burnett E, Tuttle A, Labelle A, McCray PB Jr, Naldini L, Brown B, Hough C, Lillicrap D. A microRNA-regulated and GP64-pseudotyped lentiviral vector mediates stable expression of FVIII in a murine model of Hemophilia A. Molecular Therapy. 2011 Apr;19(4):723-30.

  83. Rossetti M, Gregori S, Hauben E, Sergi Sergi L, Brown BD, Naldini L, Roncarolo MG. HIV-1-derived lentiviral vectors directly activate plasmacytoid dendritic cells, which in turn induce the maturation of myeloid dendritic cells. Human Gene Therapy. 2011 Feb;22(2):177-88.

  84. Baccarini A, Brown BD. Monitoring MicroRNA Activity and Validating MicroRNA Targets by Reporter-Based Approaches. Methods in Molecular Biology. 2010;667:215-33.

  85. Annoni A*, Brown BD*, Cantore A, Sergi Sergi L, Naldini L, Roncarolo MG. In vivo delivery of a microRNA regulated transgene induces antigen-specific regulatory T cells and promotes immunological tolerance. Blood 2009 Dec 10;114(25):5152-61 *equal contribution.

  86. Salerno E, Scaglione BJ, Coffman FD, Brown BD, Baccarini A, Fernandes H, Marti G, Raveche ES. Correcting miR-15a/16 genetic defect in New Zealand Black mouse model of CLL enhances drug sensitivity. Molecular Cancer Therapeutics. 2009 Sep;8(9):2684-92.

  87. Brown BD, Naldini L. Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications. Nature Reviews Genetics 2009 Aug;10(8):578-85.

  88. Matsui H, Shibata M, Brown B, Labelle A, Hegadorn C, Andrews C, Chuah M, VandenDriessche T, Miao CH, Hough C, Lillicrap D. A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3+ T regulatory cells. Blood. 2009 Jul 16;114(3):677-85.

  89. Gentner B, Schira G, Giustacchini A, Amendola M, Brown BD, Ponzoni M, Naldini L. Stable knockdown of microRNA in vivo by lentiviral vectors. Nature Methods. 2009 Jan;6(1):63-6.

  90. Brown BD, Gentner B, Cantore A, Colleoni S, Amendola M, Zingale A, Baccarini A, Lazzari G, Galli C, Naldini L. Endogenous microRNAs Can Be Broadly Exploited to Regulate Transgene Expression According to Tissue, Lineage, and Differentiation State. Nature Biotechnology.2007 Dec;25(12):1457-1467.

  91. Brown BD, Cantore A, Annoni A, Sergi Sergi L, Lombardo A, Della Valle P, D’Angelo A, Naldini L. A microRNA-regulated Lentiviral Vector Mediates Stable Correction of Hemophilia B Mice. Blood. 2007 Dec 15;110(13):4144-52.

  92. Matsui H, Shibata M, Brown B, Labelle A, Hegadorn C, Andrews C, Hebbel RP, Galipeau J, Hough C, Lillicrap D. Ex Vivo Gene Therapy for Hemophilia A That Enhances Safe Delivery and Sustained In Vivo FVIII Expression From Lentivirally-engineered Endothelial Progenitors.Stem Cells. 2007 Oct;25(10):2660-9.

  93. Brown BD, Sitia G, Annoni A, Hauben E, Sergi Sergi L, Zingale A, Roncarolo MG, Guidotti L, Naldini L. In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance. Blood. 2007 April; 109(7): 2797-2805.

  94. Brown BD, Venneri MA, Zingale A, Sergi Sergi L, Naldini L. Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer. Nature Medicine 2006 May;12(5):585-91.

  95. Rawle FE, Shi CX, Brown B, McKinven A, Tinlin S, Graham FL, Hough C, Lillicrap D. Heterogeneity of the immune response to adenovirus-mediated factor VIII gene therapy in different inbred hemophilic mouse strains. Journal of Gene Medicine 2004 Dec;6(12):1358-68.

  96. Brown BD, Shi CX, Webster S, Graham FL, Lillicrap DP. Helper-dependent adenoviral vectors provide Factor VIII expression in the absence of inhibitor development in a canine model of hemophilia A. Blood. 2004 Feb 1;103(3):804-10.

  97. Brown BD, Grant F, Shi CX, McKinven A, Tinlin S, Graham FL, Lillicrap DP. Factors influencing therapeutic efficacy and the host immune response to helper-dependent adenoviral gene therapy in hemophilia A mice. Journal of Thrombosis and Haemostasis. 2004 Jan;2(1):111-8.

  98. Kinkley SM, Brown BD, Lyng AT, Schep GN, Lillicrap DP, Taylor SAM. Absence of overt iron overload in two individuals compound heterozygous for a 22 base pair deletion of exon 2 and the C282Y missense mutation of the Hfe gene. Clinical Genetics. 2003 Feb;63(2):163-5.

  99. Chuah MK, Schiedner G, Thorrez L, Brown B, Johnston M, Gillijns V, Hertel S, Van Rooijen N, Lillicrap D, Collen D, VandenDriessche T, Kochanek S. Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors. Blood. 2003 Mar 1;101(5):1734-43.

  100. Brown BD and Lillicrap D. Dangerous liaisons: the role of "danger" signals in the immune response to gene therapy. Blood. 2002 Aug 15;100(4):1133-40.